Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends
authors Ventura, SPM; Silva, FAE; Quental, MV; Mondal, D; Freire, MG; Coutinho, JAP
nationality International
journal CHEMICAL REVIEWS
keywords AQUEOUS 2-PHASE SYSTEMS; ULTRASONIC-ASSISTED EXTRACTION; SOLID-PHASE EXTRACTION; BOVINE SERUM-ALBUMIN; ACID METHYL-ESTERS; CITRUS ESSENTIAL OIL; 3-PHASE PARTITIONING ILTPP; SALVIA-MILTIORRHIZA-BUNGE; FLAVUM CR. PAPAVERACEAE; COUNTER-CURRENT CHROMATOGRAPHY
abstract Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse,origins. This critical review offers a compilation on the main results achieved by the use of ionic liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to Separation processes and by suggesting some steps to overcome the current limitations.
publisher AMER CHEMICAL SOC
issn Sep-65
isbn 1520-6890
year published 2017
volume 117
issue 10
beginning page 6984
ending page 7052
digital object identifier (doi) 10.1021/acs.chemrev.6b00550
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000402498700008
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journal analysis (jcr 2017):
journal impact factor 52.613
5 year journal impact factor 55.198
category normalized journal impact factor percentile 99.708
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