Development of a biocompatible magnetic nanofluid by incorporating SPIONs in Amazonian oils
authors Gaspar, AS; Wagner, FE; Amaral, VS; Lima, SAC; Khomchenko, VA; Santos, JG; Costa, BFO; Duraes, L
nationality International
journal SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
author keywords SPION; Biocompatible magnetic nanoprobe; Amazonian oil; Mossbauer spectroscopy; X-ray diffraction; VSM
keywords CARAPA-GUIANENSIS AUBLET; THERMAL-STABILITY; SEED OIL; NANOPARTICLES; MELIACEAE; FLUIDS; TETRANORTRITERPENOIDS; TOXICITY; AGENT
abstract Higher quality magnetic nanoparticles are needed for use as magnetic nanoprobe in medical imaging techniques and cancer therapy. Moreover, the phytochemistry benefits of some Amazonian essential oils have sparked great interest for medical treatments. In this work, a magnetic nanoprobe was developed, allying the biocompatibility and superparamagnetism of iron oxide nanoparticles (SPIONs) with benefits associated with Amazonian oils from Copaiba and Andiroba trees. SPIONs were obtained by two thermal decomposition procedures and different amounts of precursors (iron acetylacetonates). Their characterization was accomplished by Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy (TEM), X-ray diffraction (XRD), Mossbauer spectroscopy and magnetization. The obtained nanoparticles composition and magnetic properties were not affected by the relative proportion of iron(II) and iron(III) in the precursor system. However, when changing the reducing and stabilizing agents the coating layer shows different compositions/relative weight the more promising SPIONs have a coating mainly composed by oleylamine and an iron oxide:coating wt% ratio of 55:45. Nanoparticles size distributions were very narrow and centred in the average size of 6-7 nm. Cellular assays confirmed the biocompatibility of SPIONs and their effective internalization in human colon cancer cells. Mossbauer/XRD results indicated maghemite as their main iron oxide. phase, but traces of magnetite proved to be present. Magnetization saturations of 57 emu/g at 5 K and 42 emu/g at 300 K were achieved. With incorporation of SPIONs into Copaiba and Andiroba essential oils, these values show a 4-fold decrease, but the supermagnetic behaviour is preserved providing the effective formation of a nanofluid. (C) 2016 Elsevier B.V. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 1386-1425
year published 2017
volume 172
beginning page 135
ending page 146
digital object identifier (doi) 10.1016/j.saa.2016.04.022
web of science category Spectroscopy
subject category Spectroscopy
unique article identifier WOS:000389093000018
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journal impact factor 3.232
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