Bioinspired Ultratough Hydrogel with Fast Recovery, Self-Healing, Injectability and Cytocompatibility
authors Azevedo, S; Costa, AMS; Andersen, A; Choi, IS; Birkedal, H; Mono, JF
nationality International
journal ADVANCED MATERIALS
author keywords catechol; chitosan; double networks; hydrogels; mussel-inspired materials
keywords DOUBLE-NETWORK HYDROGELS; HIGH MECHANICAL STRENGTH; REGENERATIVE MEDICINE; CROSS-LINKING; CHITOSAN; REPAIR; ROBUST; GELS
abstract Inspired by the mussel byssus adhesiveness, a highly hydrated polymeric structure is designed to combine, for the first time, a set of interesting features for load-bearing purposes. These characteristics include: i) a compressive strength and stiffness in the MPa range, ii) toughness and the ability to recover it upon successive cyclic loading, iii) the ability to quickly self-heal upon rupture, iv) the possibility of administration through minimally invasive techniques, such as by injection, v) the swelling ratio being adjusted to space-filling applications, and vi) cytocompatibility. Owing to these characteristics and the mild conditions employed, the encapsulation of very unstable and sensitive cargoes is possible, highlighting their potential to researchers in the biomedical field for the repair of load-bearing soft tissues, or to be used as an encapsulation platform for a variety of biological applications such as disease models for drug screening and therapies in a more realistic mechanical environment. Moreover, given the simplicity of this methodology and the enhanced mechanical performance, this strategy can be expanded to applications in other fields, such as agriculture and electronics. As such, it is anticipated that the proposed strategy will constitute a new, versatile, and cost-effective tool to produce engineered polymeric structures for both science and technology.
publisher WILEY-V C H VERLAG GMBH
issn 0935-9648
year published 2017
volume 29
issue 28
digital object identifier (doi) 10.1002/adma.201700759
subject category 6
unique article identifier WOS:000406030900021
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 27.398
5 year journal impact factor 26.444
category normalized journal impact factor percentile 97.985
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