Economic evaluation of the primary recovery of tetracycline with traditional and novel aqueous two-phase systems
authors Torres-Acosta, MA; Pereira, JFB; Freire, MG; Aguilar-Yanez, JM; Coutinho, JAP; Titchener-Hooker, NJ; Rito-Palomares, M
nationality International
journal SEPARATION AND PURIFICATION TECHNOLOGY
author keywords Tetracycline; Aqueous two-phase system (ATPS); Ionic liquids; Economic analysis; Monte Carlo simulations
keywords FISCHERI MARINE-BACTERIA; DECISION-SUPPORT TOOL; IONIC LIQUIDS; BIPHASIC SYSTEMS; POLYETHYLENE-GLYCOL; PARTITION BEHAVIOR; PERFUSION CULTURE; UNCERTAINTY; EXTRACTION; STRATEGIES
abstract Antibiotics are a key pharmaceutical to inhibit growth or kill microorganisms. They represent a profitable market and, in particular, tetracycline has been listed as an essential medicine by the WHO. Therefore it is important to improve their production processes. Recently novel and traditional aqueous two-phase systems for the extraction have been developed with positive results. The present work performs an economic analysis of the production and recovery of tetracycline through the use of several ATPS through bioprocess modeling using specialized software (BioSolve, Biopharm Services Ltd, UK) to determine production costs per gram (CoG/g). First, a virtual model was constructed using published data on the recovery of tetracycline and extended to incorporate uncertainties. To determine how the model behaved, a sensitivity analysis and Monte Carlo simulations were performed. Results showed that ATPS formed by cholinium chloride/K3PO4 was the best option to recover tetracycline, as it had the lowest CoG/g (US$ 672.83/g), offered the highest recovery yield (92.42%), second best sample input capacity (45% of the ATPS composition) and one of the lowest materials contribution to cost. The ionic liquid-based method of ATPS is a promising alternative for recovering tetracycline from fermentation broth.
publisher ELSEVIER SCIENCE BV
issn 1383-5866
year published 2018
volume 203
beginning page 178
ending page 184
digital object identifier (doi) 10.1016/j.seppur.2018.04.041
web of science category Engineering, Chemical
subject category Engineering
unique article identifier WOS:000436051500020
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