Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies
authors Santos, SCND; Sigurjonsson, OE; Custodio, CD; Mano, JFCD
nationality International
journal TISSUE ENGINEERING PART B-REVIEWS
author keywords platelet-rich plasma; platelets; platelet lysates; personalized medicine
keywords PLATELET-RICH PLASMA; RANDOMIZED CONTROLLED-TRIAL; MESENCHYMAL STROMAL CELLS; FETAL BOVINE SERUM; CONTROLLED-RELEASE; ENDOTHELIAL-CELL; DOUBLE-BLIND; STEM-CELLS; LYSATE GEL; FIBRIN
abstract Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs. In the last years, a great development has been witnessed on PRP based biomaterials, with both structural and functional purposes. In this study we overview the most relevant PRP applications encompassing PRP based materials for tissue engineering and regenerative medicine. This review also summarizes the challenges in the fields of tissue engineering and regenerative medicine and provides a perspective on future directions.
publisher MARY ANN LIEBERT, INC
issn 1937-3368
year published 2018
volume 24
issue 6
beginning page 454
ending page 462
digital object identifier (doi) 10.1089/ten.teb.2018.0008
web of science category Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology
subject category Cell Biology; Biotechnology & Applied Microbiology
unique article identifier WOS:000435982800001
  ciceco authors
  impact metrics
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg