Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses
authors Lavrador, P; Gaspar, VM; Mano, JF
nationality International
journal JOURNAL OF CONTROLLED RELEASE
author keywords Stimuli-responsive, nanoparticles; Bone therapeutics delivery; Controlled release
keywords TARGETED DRUG-DELIVERY; TUMOR MICROENVIRONMENT; CATHEPSIN-K; THERMOSENSITIVE NANOPARTICLES; ANTIINFLAMMATORY PEPTIDES; MATRIX METALLOPROTEINASES; BIOLOGICAL BARRIERS; INTRACELLULAR DRUG; POLYMERIC MICELLES; CONTROLLED-RELEASE
abstract The development of stimuli-responsive nanomedicines with tunable cargo release is gathering an increased applicability in bone regeneration and precision biomedicine. Yet, the formulation of nanocarriers that explore skeletal-specific stimuli remains remarkably challenging to materialize due to several endogenous and disease-specific barriers that must be considered during particle design stages. Such anatomo-physiological constrains ultimately hinder nanocarriers bioavailability in target bone tissues and impact the overall therapeutic outcome. This review aims to showcase and critically discuss the hurdles encountered upon responsive nanocarriers delivery in the context of skeletal diseases or tissue regeneration scenarios. Such focus is complemented with an in-depth and up-to-date analysis of advances in the development of stimuli-responsive, bone-focused delivery systems. In a holistic perspective, a deeper knowledge of human osteology combined with advances in materials functionalization via simple precision-chemistry is envisioned to incite the manufacture of stimuli-triggered nanomedicines with more realistic potential for clinical translation.
publisher ELSEVIER SCIENCE BV
issn 0168-3659
year published 2018
volume 273
beginning page 51
ending page 67
digital object identifier (doi) 10.1016/j.jconrel.2018.01.021
web of science category Chemistry, Multidisciplinary; Pharmacology & Pharmacy
subject category Chemistry; Pharmacology & Pharmacy
unique article identifier WOS:000426298100006
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journal impact factor 7.877
5 year journal impact factor 8.683
category normalized journal impact factor percentile 91.793
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