Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications
authors Bastos, AR; Vicente, CMS; Oliveira-Silva, R; Silva, NJO; Tacao, M; da Costa, JP; Lima, M; Andre, PS; Ferreira, RAS
nationality International
journal SENSORS
author keywords photonic; integrated optics; sol-gel; biosensors; E. coli; organic-inorganic hybrid
keywords ESCHERICHIA-COLI; REFRACTIVE-INDEX; LABEL-FREE; FIBER TECHNOLOGY; BACTERIAL-GROWTH; PERSPECTIVE; PERFORMANCE; CELL
abstract The development of portable low-cost integrated optics-based biosensors for photonics-on-a-chip devices for real-time diagnosis are of great interest, offering significant advantages over current analytical methods. We report the fabrication and characterization of an optical sensor based on a Mach-Zehnder interferometer to monitor the growing concentration of bacteria in a liquid medium. The device pattern was imprinted on transparent self-patternable organic-inorganic di-ureasil hybrid films by direct UV-laser, reducing the complexity and cost production compared with lithographic techniques or three-dimensional (3D) patterning using femtosecond lasers. The sensor performance was evaluated using, as an illustrative example, E. coli cell growth in an aqueous medium. The measured sensitivity (2 x 10(-4) RIU) and limit of detection (LOD = 2 x 10(-4)) are among the best values known for low-refractive index contrast sensors. Furthermore, the di-ureasil hybrid used to produce this biosensor has additional advantages, such as mechanical flexibility, thermal stability, and low insertion losses due to fiber-device refractive index mismatch (similar to 1.49). Therefore, the proposed sensor constitutes a direct, compact, fast, and cost-effective solution for monitoring the concentration of lived-cells.
publisher MDPI
issn 1424-8220
year published 2018
volume 18
issue 3
digital object identifier (doi) 10.3390/s18030840
web of science category Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
subject category Chemistry; Electrochemistry; Instruments & Instrumentation
unique article identifier WOS:000428805300161
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journal analysis (jcr 2017):
journal impact factor 2.475
5 year journal impact factor 3.014
category normalized journal impact factor percentile 61.717
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