Bone physiology as inspiration for tissue regenerative therapies
authors Lopes, D; Martins-Cruz, C; Oliveira, MB; Mano, JF
nationality International
journal BIOMATERIALS
author keywords Bone physiology; Bone microenvironment; Biomaterials; Biomimetics
keywords MESENCHYMAL STEM-CELLS; HUMAN-INDUCED PLURIPOTENT; NONCOLLAGENOUS MATRIX PROTEINS; ENDOTHELIAL PROGENITOR CELLS; CALCIUM-PHOSPHATE CERAMICS; OSTEOBLAST-LIKE CELLS; COLLAGEN TYPE-III; OSTEOGENIC DIFFERENTIATION; IN-VITRO; GROWTH-FACTOR
abstract The development, maintenance of healthy bone and regeneration of injured tissue in the human body comprise a set of intricate and finely coordinated processes. However, an analysis of current bone regeneration strategies shows that only a small fraction of well-reported bone biology aspects has been used as inspiration and transposed into the development of therapeutic products. Specific topics that include inter-scale bone structural organization, developmental aspects of bone morphogenesis, bone repair mechanisms, role of specific cells and heterotypic cell contact in the bone niche (including vascularization networks and immune system cells), cell-cell direct and soluble-mediated contact, extracellular matrix composition (with particular focus on the non-soluble fraction of proteins), as well as mechanical aspects of native bone will be the main reviewed topics. In this Review we suggest a systematic parallelization of (i) fundamental well-established biology of bone, (ii) updated and recent advances on the understanding of biological phenomena occurring in native and injured tissue, and (iii) critical discussion of how those individual aspects have been translated into tissue regeneration strategies using biomaterials and other tissue engineering approaches. We aim at presenting a perspective on unexplored aspects of bone physiology and how they could be translated into innovative regeneration-driven concepts.
publisher ELSEVIER SCI LTD
issn 0142-9612
year published 2018
volume 185
beginning page 240
ending page 275
digital object identifier (doi) 10.1016/j.biomaterials.2018.09.028
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000448494500020
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 10.317
5 year journal impact factor 9.656
category normalized journal impact factor percentile 97.331
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg