Effects of polymethylmethacrylate nanoplastics on Dicentrarchus labrax
authors Brandts, I; Teles, M; Tvarijonaviciute, A; Pereira, ML; Martins, MA; Tort, L; Oliveira, M
nationality International
journal GENOMICS
author keywords Nanoplastics; Sea bass; Lipid metabolism; Gene expression
keywords POLYSTYRENE NANOPARTICLES; SKIN MUCUS; STRESS; MICROPLASTICS; METABOLISM; EXPRESSION; ENVIRONMENT; TOXICITY; TISSUE; GENES
abstract The present study aimed to evaluate the effects of similar to 45 nm nanoplastics (NPs) on the marine fish Dicentrarchus labrax after a short-term exposure. Animals were exposed to a concentration range of NPs for 96 h and liver, plasma and skin mucus were sampled. Assessed endpoints included biochemical biomarkers and expression of genes related to lipid metabolism, immune system and general cell stress. Abundance of mRNA transcripts related to lipid metabolism, ppara and ppary, were significantly increased after exposure to NPs. Biochemical endpoints revealed decreased esterase activity levels in plasma, suggesting that the immune system of fish might be compromised by exposure to NPs. Moreover, significantly lower levels of alkaline phosphatase were found in the skin mucus of animals exposed to NPs. The present results suggest that NPs may represent a hazard to this marine fish, potentially interfering with the metabolism of lipids and the correct function of the immune response.
publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
issn 0888-7543
year published 2018
volume 110
issue 6
beginning page 435
ending page 441
digital object identifier (doi) 10.1016/j.ygeno.2018.10.006
web of science category Biotechnology & Applied Microbiology; Genetics & Heredity
subject category Biotechnology & Applied Microbiology; Genetics & Heredity
unique article identifier WOS:000451057100014
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journal impact factor 6.205
5 year journal impact factor 4.149
category normalized journal impact factor percentile 90.089
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