Synthesis and Characterization of Rare-Earth Orthoferrite LnFeO(3) Nanoparticles for Bioimaging
authors Pinho, SLC; Amaral, JS; Wattiaux, A; Duttine, M; Delville, MH; Geraldes, CFGC
nationality International
journal EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
author keywords Nanoparticles; Lanthanides; Orthoferrites; Relaxivity; Imaging agents
keywords PEROVSKITE-TYPE OXIDES; MRI CONTRAST AGENTS; MULTIFUNCTIONAL MAGNETIC NANOPARTICLES; FE-57 MOSSBAUER-SPECTROSCOPY; BIOMEDICAL APPLICATIONS; THIN-FILMS; HYDROTHERMAL SYNTHESIS; THERMAL-DECOMPOSITION; GD2O3 NANOPARTICLES; COMBUSTION METHOD
abstract A combination of sol-gel synthesis and thermal decomposition was developed for preparing nanosized, perovskite-type LnFeO(3) (Ln = Eu, Gd, Tb) powders. Perovskite-type powders with crystalline particles of 100 nm average size, as determined by transmission electron microscopy (TEM), could be obtained after a thermal treatment at 800 degrees C. The perovskite nanoparticles (NPs) were further characterized by X-ray powder diffraction and Mossbauer spectroscopy. These were in agreement with the pure perovskite LnFeO(3) structure with the expected Zeeman sextet corresponding to a magnetically ordered phase. Magnetization measurements [M(H)] at 5 K and 300 K showed a behavior that is dominated by antiferromagnetic interactions and weak ferromagnetism in EuFeO3, while for Ln = Gd, Tb, they were dominated by the low ordering temperature Ln magnetic sublattice. The colloidal aqueous NPs suspensions exhibited no significant leaching of free Ln(3+) ions. Their relaxivities define them as potential T-2 MRI contrast agents for further biomedical applications. The NPs showed fast uptake and no cytotoxicity at concentrations below 62.5 mu g/mL with respect to Hela cells.
publisher WILEY-V C H VERLAG GMBH
issn 1434-1948
year published 2018
issue 31
beginning page 3570
ending page 3578
digital object identifier (doi) 10.1002/ejic.201800468
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000442492500006
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journal impact factor 2.507
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