Development of novel Cu(I) compounds with vitamin B-1 derivative and their potential application as anticancer drugs
authors Brandao, P; Guieu, S; Correia-Branco, A; Silva, C; Martel, F
nationality International
journal INORGANICA CHIMICA ACTA
author keywords Copper(I); Vitamin B-1 derivatives; Thiochrome; Caco-2 cells
keywords COPPER-COMPLEXES SYNTHESIS; METAL-ION INTERACTIONS; CRYSTAL-STRUCTURE; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CYTOTOXIC PROPERTIES; MOLECULAR-STRUCTURE; ANTITUMOR-ACTIVITY; 2 SALTS; THIAMINE
abstract The synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu-4[(mu(3)-thiocrome)(2)Cl-4]center dot 2(H2O)}(n) 1, and Cu-2[(mu(2)-thiocrome)(2)Cl-2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain structure based on the linkage of two crystallographic different copper centers and thiochrome ligand through the N(1), N (2) and N(3) nitrogen atoms. Compound 2 is a 0D dimeric copper structure assembled by two thiochrome ligands. For both compounds, the copper(I) centers exhibits a distorted trigonal pyramidal geometry. The antitumor capacity of both compounds was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability. The two compounds showed similar IC50 values, and were slightly more potent than cisplatin, against the same cell line.
publisher ELSEVIER SCIENCE SA
issn 0020-1693
isbn 1873-3255
year published 2019
volume 487
beginning page 287
ending page 294
digital object identifier (doi) 10.1016/j.ica.2018.12.017
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000456799100038
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journal analysis (jcr 2019):
journal impact factor 2.304
5 year journal impact factor 1.926
category normalized journal impact factor percentile 56.667
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