Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
authors Bjorge, IM; Choi, IS; Correia, CR; Mano, JF
nationality International
journal NANOSCALE
keywords MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR
abstract Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
publisher ROYAL SOC CHEMISTRY
issn 2040-3364
year published 2019
volume 11
issue 35
beginning page 16214
ending page 16221
digital object identifier (doi) 10.1039/c9nr06267j
web of science category Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000485971900004

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