Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy
authors Pereira, DSM; Cardoso, BD; Rodrigues, ARO; Amorim, CO; Amaral, VS; Almeida, BG; Queiroz, MJRP; Martinho, O; Baltazar, F; Calhelha, RC; Ferreira, ICFR; Coutinho, PJG; Castanheira, EMS
nationality International
journal PHARMACEUTICS
author keywords calcium ferrite nanoparticles; magnetoliposomes; new antitumor drugs; thienopyridine derivatives; breast cancer therapy
keywords NILE RED; MAGNETIC NANOPARTICLES; QUANTUM YIELDS; IN-VITRO; LIPOSOMES; NANOCARRIERS; FLUORESCENCE; ANTITUMOR; CYTOTOXICITY; VESICLES
abstract Magnetoliposomes containing calcium ferrite (CaFe2O4) nanoparticles were developed and characterized for the first time. CaFe2O4 nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 +/- 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (>= 70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.
publisher MDPI
isbn 1999-4923
year published 2019
volume 11
issue 9
digital object identifier (doi) 10.3390/pharmaceutics11090477
web of science category Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy
unique article identifier WOS:000489151700010
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journal analysis (jcr 2019):
journal impact factor 4.421
5 year journal impact factor Not Available
category normalized journal impact factor percentile 83.889
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