Microparticles in Contact with Cells: From Carriers to Multifunctional Tissue Modulators
authors Neto, MD; Oliveira, MB; Mano, JF
nationality International
journal TRENDS IN BIOTECHNOLOGY
keywords OSTEOGENIC DIFFERENTIATION; SCAFFOLDING ELEMENTS; GROWTH-FACTORS; STEM-CELLS; MICROCARRIERS; FABRICATION; HYDROGEL; CULTURE; GENERATION; EXPANSION
abstract For several decades microparticles have been exclusively and extensively explored as spherical drug delivery vehicles and large-scale cell expansion carriers. More recently, microparticulate structures gained interest in broader bioengineering fields, integrating myriad strategies that include bottom-up tissue engineering, 3D bioprinting, and the development of tissue/disease models. The concept of bulk spherical micrometric particles as adequate supports for cell cultivation has been challenged, and systems with finely tuned geometric designs and (bio)chemical/physical features are current key players in impacting technologies. Herein, we critically review the state of the art and future trends of biomaterial microparticles in contact with cells and tissues,excluding internalization studies, and with emphasis on innovative particle design and applications.
publisher ELSEVIER SCIENCE LONDON
issn 0167-7799
isbn 1879-3096
year published 2019
volume 37
issue 9
beginning page 1011
ending page 1028
digital object identifier (doi) 10.1016/j.tibtech.2019.02.008
web of science category Biotechnology & Applied Microbiology
subject category Biotechnology & Applied Microbiology
unique article identifier WOS:000481640500012
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 14.343
5 year journal impact factor 15.157
category normalized journal impact factor percentile 98.397
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