Rationalizing the Phase Behavior of Triblock Copolymers through Experiments and Molecular Simulations
authors Perez-Sanchez, G; Vicente, FA; Schaeffer, N; Cardoso, IS; Ventura, SPM; Jorge, M; Coutinho, JAP
nationality International
journal JOURNAL OF PHYSICAL CHEMISTRY C
keywords COARSE-GRAINED MODEL; POLY(ETHYLENE OXIDE); DYNAMICS SIMULATIONS; FORCE-FIELD; POLY(PROPYLENE OXIDE); AQUEOUS-SOLUTIONS; BLOCK-COPOLYMERS; IONIC LIQUIDS; COMPUTER-SIMULATION; TEMPLATED SYNTHESIS
abstract In this paper, we develop a new coarse-grained model, under the MARTINI framework, for Pluronic block copolymers that is able to describe the self-assembly mechanism and reproduce experimental micelle sizes and shapes. Previous MARTINI-type Pluronic models were unable to produce realistic micelles in aqueous solution, and thus our model represents a marked improvement over existing approaches. We then applied this model to understand the effects of polymer structure on the cloud point temperature measured experimentally for a series of Pluronics, including both normal and reverse copolymers. It was observed that high polyoxypropylene glycol content leads to dominant hydrophobic interactions and a lower cloud point temperature, while high hydrophilic polyoxyethylene glycol content shields the micelles against aggregation and hence leads to a higher cloud point temperature. As the concentration increases, the effect of polymer architecture (normal versus reverse) starts to dominate, with reverse Pluronics showing a lower cloud point temperature. This was shown to be due to the increased formation of cross-links between neighboring micelles in these systems, which promote micelle aggregation. Our results shed new light on these fascinating systems and open the door to increased control of their thermal responsive behavior.
publisher AMER CHEMICAL SOC
issn 1932-7447
year published 2019
volume 123
issue 34
beginning page 21224
ending page 21236
digital object identifier (doi) 10.1021/acs.jpcc.9b04099
web of science category Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000484075800061

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