Acanthamoeba in Southeast Asia - Overview and Challenges
authors Bunsuwansakul, C; Mahboob, T; Hounkong, K; Laohaprapanon, S; Chitapornpan, S; Jawjit, S; Yasiri, A; Barusrux, S; Bunluepuech, K; Sawangjaroen, N; Salibay, CC; Kaewjai, C; Pereira, MD; Nissapatorn, V
nationality International
journal KOREAN JOURNAL OF PARASITOLOGY
author keywords Acanthamoeba; clinico-epidemiology; medicinal plant; molecular; nanotechnology; Southeast Asia
keywords FREE-LIVING AMEBAS; BIOLOGICAL-PROPERTIES; KERATITIS; DIAGNOSIS; INFECTION; IDENTIFICATION; GENOTYPE; SPP.; EPIDEMIOLOGY; CYSTS
abstract Acanthamoeba, one of free-living amoebae (FLA), remains a high risk of direct contact with this protozoan parasite which is ubiquitous in nature and man-made environment. This pathogenic FLA can cause sight-threatening amoebic keratitis (AK) and fatal granulomatous amoebic encephalitis (GAE) though these cases may not commonly be reported in our clinical settings. Acanthamoeba has been detected from different environmental sources namely; soil, water, hot-spring, swimming pool, air-conditioner, or contact lens storage cases. The identification of Acanthamoeba is based on morphological appearance and molecular techniques using PCR and DNA sequencing for clinico-epidemiological purposes. Recent treatments have long been ineffective against Acanthamoeba cyst, novel anti-Acanthamoeba agents have therefore been extensively investigated. There are efforts to utilize synthetic chemicals, lead compounds from medicinal plant extracts, and animal products to combat Acanthamoeba infection. Applied nanotechnology, an advanced technology, has shown to enhance the anti-Acanthamoeba activity in the encapsulated nanoparticles leading to new therapeutic options. This review attempts to provide an overview of the available data and studies on the occurrence of pathogenic Acanthamoeba among the Association of Southeast Asian Nations (ASEAN) members with the aim of identifying some potential contributing factors such as distribution, demographic profile of the patients, possible source of the parasite, mode of transmission and treatment. Further, this review attempts to provide future direction for prevention and control of the Acanthamoeba infection.
publisher KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
issn 0023-4001
year published 2019
volume 57
issue 4
beginning page 341
ending page 357
digital object identifier (doi) 10.3347/kjp.2019.57.4.341
web of science category Parasitology
subject category Parasitology
unique article identifier WOS:000486567600002
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journal analysis (jcr 2017):
journal impact factor 1.207
5 year journal impact factor 1.221
category normalized journal impact factor percentile 22.973
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