Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment
authors Carvalho, JPF; Silva, ACQ; Bastos, V; Oliveira, H; Pinto, RJB; Silvestre, AJD; Vilela, C; Freire, CSR
nationality International
journal NANOMATERIALS
author keywords bacterial nanocellulose; hyaluronic acid; diclofenac; nanostructured patches; drug delivery; aphthous stomatitis
keywords BACTERIAL CELLULOSE MEMBRANES; IN-VITRO; TRANSDERMAL DELIVERY; PHYSICAL-PROPERTIES; TOPICAL DICLOFENAC; CONTROLLED-RELEASE; COMPOSITES; DISSOLUTION; EFFICACY; SYSTEMS
abstract Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 degrees C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.
publisher MDPI
year published 2020
volume 10
issue 4
digital object identifier (doi) 10.3390/nano10040628
web of science category Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000539577200031
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journal analysis (jcr 2019):
journal impact factor 4.324
5 year journal impact factor 4.514
category normalized journal impact factor percentile 65.762
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