Advanced Bottom-Up Engineering of Living Architectures
authors Gaspar, VM; Lavrador, P; Borges, J; Oliveira, MB; Mano, JF
nationality International
journal ADVANCED MATERIALS
author keywords 3D bioarchitectures; bottom-up assembly; tissue engineering
keywords SHEAR-THINNING HYDROGELS; STIMULI-RESPONSIVE NANOCARRIERS; MAGNETIC CELLULAR SPHEROIDS; MESENCHYMAL STEM-CELLS; SURFACE SIALIC ACIDS; TISSUE CONSTRUCTS; EXTRACELLULAR-MATRIX; POLYMERIC NANOPARTICLES; SPATIOTEMPORAL CONTROL; BUILDING-BLOCKS
abstract Bottom-up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom-up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular-rich structures or multicomponent cell-biomaterial synergies are described. An up-to-date critical overview of long-term existing and rapidly emerging technologies for integrative bottom-up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell-biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.
publisher WILEY-V C H VERLAG GMBH
issn 0935-9648
isbn 1521-4095
year published 2020
volume 32
issue 6
digital object identifier (doi) 10.1002/adma.201903975
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000501829800001
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journal analysis (jcr 2019):
journal impact factor 27.398
5 year journal impact factor 26.444
category normalized journal impact factor percentile 97.985
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