The Potential of Fucose-Containing Sulfated Polysaccharides As Scaffolds for Biomedical Applications
authors Nunes, C; Coimbra, MA
nationality International
journal CURRENT MEDICINAL CHEMISTRY
author keywords Fucans; fucoidans; antitumoral; structural characteristics; delivery devices; tissue engineering
keywords IRON-OXIDE NANOPARTICLES; BROWN-ALGAE; IN-VITRO; SURFACE MODIFICATION; STRUCTURAL FEATURES; ANTIVIRAL ACTIVITY; FUCOIDAN; CHITOSAN; CANCER; ANTICOAGULANT
abstract Marine environments have a high quantity and diversity of sulfated polysaccharides. In coastal regions brown algae are the most abundant biomass producers and their cell walls have fucose-containing sulfated polysaccharides (FCSP), known as fucans and/or fucoidans. These sulfated compounds have been widely researched for their biomedical properties, namely the immunomodulatory, haemostasis, pathogen inhibition, anti-inflammatory capacity, and antitumoral. These activities are probably due to their ability to mimic the carbohydrate moieties of mammalian glycosaminoglycans. Therefore, the FCSP are interesting compounds for application in health-related subjects, mainly for developing scaffolds for delivery systems or tissue regeneration. FCSP showed potential for these applications also due to their ability to form stable 3D structures with other polymers able to entrap therapeutic agents or cell and growth factors, besides their biocompatibility and biodegradability. However, for the clinical use of these biopolymers well-defined reproducible molecules are required in order to accurately establish relationships between structural features and human health applications.
publisher BENTHAM SCIENCE PUBL LTD
issn 0929-8673
isbn 1875-533X
year published 2019
volume 26
issue 35
beginning page 6399
ending page 6411
digital object identifier (doi) 10.2174/0929867326666181213093718
web of science category Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy
subject category Biochemistry & Molecular Biology; Pharmacology & Pharmacy
unique article identifier WOS:000502614500004
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journal analysis (jcr 2019):
journal impact factor 4.184
5 year journal impact factor 3.797
category normalized journal impact factor percentile 76.097
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