Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

authors	Barra, A; Alves, Z; Ferreira, NM; Martins, MA; Oliveira, H; Ferreira, LP; Cruz, MM; Carvalho, MD; Neumayer, SM; Rodriguez, BJ; Nunes, C; Ferreira, P
nationality	International
journal	JOURNAL OF MATERIALS CHEMISTRY B
keywords	MAGNETIC HYPERTHERMIA; ANTIOXIDANT ACTIVITY; OXIDE NANOPARTICLES; CONDUCTIVE CHITOSAN; GRAPHENE; FILMS; FIELD; FUNCTIONALIZATION; NANOSTRUCTURES; NANOCOMPOSITES
abstract	Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe3-xO4) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe3-xO4 nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (similar to 8 MPa) chitosan films to stiff (similar to 285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 degrees C in 45 s for the 50% rGO-Fe3-xO4 film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.
publisher	ROYAL SOC CHEMISTRY
issn	2050-750X
isbn	2050-7518
year published	2020
volume	8
issue	6
beginning page	1256
ending page	1265
digital object identifier (doi)	10.1039/c9tb02067e
web of science category	Materials Science, Biomaterials
subject category	Materials Science
unique article identifier	WOS:000514632000014