Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation
authors Kim, JY; Kim, S; Han, S; Han, SY; Passos, CP; Seo, J; Lee, H; Kang, EK; Mano, JF; Coimbra, MA; Park, JH; Choi, IS
nationality International
journal CHEMNANOMAT
author keywords coffee melanoidin; film formation; cell encapsulation; surface engineering; carbohydrates
keywords SURFACE-INITIATED POLYMERIZATION; RING-OPENING POLYMERIZATION; INDIVIDUAL MAMMALIAN-CELLS; RADICAL POLYMERIZATION; MOLECULAR-WEIGHT; P-DIOXANONE; THIN-FILMS; ENCAPSULATION; BIOSILICIFICATION; POLYSACCHARIDES
abstract The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.
publisher WILEY-V C H VERLAG GMBH
issn 2199-692X
year published 2020
volume 6
issue 3
beginning page 379
ending page 385
digital object identifier (doi) 10.1002/cnma.202000004
web of science category Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000513689200001
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journal impact factor 3.384
5 year journal impact factor 3.42
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