Comparative Cr, As and CCA induced Cytostaticity in mice kidney: A contribution to assess CCA toxicity
authors Matos, RC; Oliveira, H; Fonseca, HMAC; Morais, S; Sharma, B; Santos, C; Pereira, MD
nationality International
journal ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
author keywords CCA; Arsenite; Chromium; Clastogenicity; Cytostaticity; Kidney
keywords CHROMATED COPPER ARSENATE; TREATED WOOD; CHILDRENS EXPOSURE; CELL-CYCLE; CHROMIUM; PRESERVATIVES; COMBINATIONS; DICHROMATE; APOPTOSIS; METALS
abstract CCA (Chromium Copper Arsenate) treated wood, widely used in outdoor residential structures and playgrounds, poses considerable dangers of leaching of its components to the environment. In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3) and arsenic pentoxide (As2O5) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 h of animal exposure. While Cr had no statistically significant cytostatic effects, As2O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage. The effects of CCA in S-phase were similar, but more severe than those of As2O5. Since environmental and public health hazards due to the long durability of CCA-treated wood products, these data confirm that CCA has profoundly toxic effects on cell cycle, distinct from the compounds themselves. These cytostatic effects support cell cycle dynamics as a valuable endpoint to assess the toxicity of remaining CCA-treated infrastructures, and the expected increased waste stream over the coming decades.
publisher ELSEVIER
issn 1382-6689
isbn 1872-7077
year published 2020
volume 73
digital object identifier (doi) 10.1016/j.etap.2019.103297
web of science category Environmental Sciences; Pharmacology & Pharmacy; Toxicology
subject category Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
unique article identifier WOS:000509623200012
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