Perinatal tissues and cells in tissue engineering and regenerative medicine
authors Deus, IA; Mano, JF; Custodio, CA
nationality International
journal ACTA BIOMATERIALIA
author keywords Perinatal tissues; Stem cells; ECM; Amniotic membrane; Umbilical cord; Tissue engineering
keywords MESENCHYMAL STEM-CELLS; HUMAN UMBILICAL-CORD; HUMAN AMNIOTIC MEMBRANE; PLACENTA-DERIVED CELLS; HUMAN BONE-MARROW; EXTRACELLULAR-MATRIX; HEMATOPOIETIC STEM; STROMAL CELLS; EPITHELIAL-CELLS; IN-VITRO
abstract Perinatal tissues are an abundant source of human extracellular matrix proteins, growth factors and stem cells with proved potential use in a wide range of therapeutic applications. Due to their placental origin, these tissues possess unique biological properties, including being angiogenic, anti-inflammatory, anti-fibrotic, anti-microbial and immune privileged. Additionally, as a temporary organ, placenta is usually discarded as a medical waste, thus providing an easily available, cost effective, 'unlimited' and ethical source of raw materials. Although some of these tissues, such as the amniotic membrane and umbilical cord, have been used in clinical practices, most of them continue to be highly under explored. This review aims to outline the most relevant applications of perinatal tissues as a source of biomaterials and stem cells in the exciting fields of tissue engineering and regenerative medicine (TERM), as well as highlight how these solutions can be used to overcome the shortage of adequate scaffolds and cell sources that currently hampers the translation of TERM strategies towards clinical settings. Statement of Significance Stem cells and extracellular matrix derived from perinatal tissues such as placenta and umbilical cord, have drawn great attention for use in a wide variety of applications in the biomedical field. Due to their origin, these tissues possess unique biological properties, including being angiogenic, anti-inflammatory, anti-fibrotic, anti-microbial and immune privileged. Also they are typically considered medical waste, thus providing an easily available, cost effective, 'unlimited' and ethical source of raw materials. This work aims to present and discuss the most relevant applications of perinatal tissues as a source of biomaterials and stem cells in the exciting fields of tissue engineering and regenerative medicine (TERM). (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 1742-7061
isbn 1878-7568
year published 2020
volume 110
beginning page 1
ending page 14
digital object identifier (doi) 10.1016/j.actbio.2020.04.035
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000538151500001
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 7.242
5 year journal impact factor 7.502
category normalized journal impact factor percentile 89.769
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg