Responsive laminarin-boronic acid self-healing hydrogels for biomedical applications
authors Amaral, AJR; Gaspar, VM; Mano, JF
nationality International
journal POLYMER JOURNAL
keywords POLYMERS; OXIDATION
abstract The precise chemical modification of marine-derived biopolymers provides a unique opportunity for fabricating a toolbox of bioactive (bio)materials with modulated physicochemical and biological properties. Herein, the beta-glucan laminarin was functionalized with phenylboronic acid (PBA) moieties that impart chemical reactivity toward diol-containing polymers via boronate esterification. The modification, which involved a two-pot reaction, was successfully confirmed by nuclear magnetic resonance spectroscopy. The resultant biopolymer readily established boronate ester-crosslinked hydrogels with poly(vinyl alcohol) (PVA) within seconds under physiological conditions. These hydrogels exhibited improved rheological properties, which were easily tunable, and revealed a rapid self-healing behavior upon rupture. Moreover, boronate ester bonds enabled the fabrication of reactive oxygen species-responsive and shear-thinning gels that can be administered in situ and respond to the oxidation state of the surrounding microenvironment. Importantly, due to the catalyst-free and mild-crosslinking conditions, the generated laminarin-PBA/PVA hydrogels did not show toxicity upon direct contact with preosteoblasts for up to 48 h, and thus constitute a promising platform for tissue engineering and drug delivery applications.
publisher NATURE PUBLISHING GROUP
issn 0032-3896
year published 2020
volume 52
issue 8
beginning page 997
ending page 1006
digital object identifier (doi) 10.1038/s41428-020-0348-3
web of science category Polymer Science
subject category Polymer Science
unique article identifier WOS:000529488600001

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