Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models
authors Ferreira, LP; Gaspar, VM; Mano, JF
nationality International
journal TRENDS IN BIOTECHNOLOGY
keywords CELL-DERIVED MATRICES; MECHANICAL-PROPERTIES; CROSS-LINKING; LIVER MATRIX; CANCER CELLS; TISSUE; COLLAGEN; SCAFFOLD; CULTURE; PHENOTYPE
abstract Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the tumor microenvironment. We review current and upcoming methodologies for chemical modification of dECM-based biomaterials and advanced bioprocessing into organotypic 3D solid tumor models. A comprehensive review of disruptive advances and shortcomings of exploring dECM-based biomaterials for recapitulating the native tumor-supporting matrix is also provided. We hope to drive the discussion on how 3D dECM testing platforms can be leveraged for generating microphysiological tumor surrogates that generate more robust and predictive data on therapeutic bioperformance.
publisher ELSEVIER SCIENCE LONDON
issn 0167-7799
isbn 1879-3096
year published 2020
volume 38
issue 12
beginning page 1397
ending page 1414
digital object identifier (doi) 10.1016/j.tibtech.2020.04.006
web of science category Biotechnology & Applied Microbiology
subject category Biotechnology & Applied Microbiology
unique article identifier WOS:000590396200010
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 14.343
5 year journal impact factor 15.157
category normalized journal impact factor percentile 98.397
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