Evaluation of Cation Influence on the Formation and Extraction Capability of Ionic-Liquid-Based Aqueous Biphasic Systems
authors Neves, CMSS; Ventura, SPM; Freire, MG; Marrucho, IM; Coutinho, JAP
nationality International
journal JOURNAL OF PHYSICAL CHEMISTRY B
keywords PHASE-DIAGRAM DATA; 2-PHASE SYSTEMS; MUTUAL SOLUBILITIES; POLYETHYLENE-GLYCOL; PARTITIONING BEHAVIOR; PLUS SUCROSE; 298.15 K; WATER; SALT; SEPARATION
abstract In addition to the large range of applications proposed in literature, ionic liquids (ILs) have been recently reported to be able to form aqueous biphasic systems (ABS). They could thus be interesting media in biotechnological applications for the separation and purification of vital biomolecules. Therefore, in this work, a systematic study involving a large number of imidazolium-based ILs was conducted to provide new information related to ILs' ABS-promoting capability and extraction ability. For that purpose, the influence of the number of alkyl groups present at the cation, the cation side alkyl chain length, and the presence of double bonds, aromatic rings, and hydroxyl groups on this alkyl chain were evaluated. Ternary phase diagrams of the ABS formed by these ILs and K(3)PO(4) and the respective tie-lines were measured and presented. The ABS here investigated were further characterized for the first time accordingly to their extractive potential for amino acids, where L-tryptophan was selected as a model biomolecule. The partition coefficients here obtained were shown to be substantially larger than those observed in conventional ABS, demonstrating therefore the fine potential of IL-based ABS for biomolecules separation and purification.
publisher AMER CHEMICAL SOC
issn 1520-6106
year published 2009
volume 113
issue 15
beginning page 5194
ending page 5199
digital object identifier (doi) 10.1021/jp900293v
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000265030500030
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journal impact factor 3.146
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