Evaluation of Anion Influence on the Formation and Extraction Capacity of Ionic-Liquid-Based Aqueous Biphasic Systems
authors Ventura, SPM; Neves, CMSS; Freire, MG; Marrucho, IM; Oliveira, J; Coutinho, JAP
nationality International
journal JOURNAL OF PHYSICAL CHEMISTRY B
keywords 2-PHASE SYSTEMS; PHASE-BEHAVIOR; MUTUAL SOLUBILITIES; POLYETHYLENE-GLYCOL; PLUS SUCROSE; SALTING-OUT; TEMPERATURE; WATER; FERMENTATION; POLARITY
abstract Extractive fermentation using aqueous biphasic systems (ABS) is a promising separation process since it provides a nondenaturing environment for biomolecules and improves the stability of cells. Due to environmental concerns and toxicity issues related with common volatile organic solvents, ionic liquids (ILs), a new class of nonvolatile alternative solvents, are being currently investigated for extraction purposes. In this work, a wide range of imidazolium-based ILs was studied aiming at obtaining new insights regarding their ability toward the formation of ABS and their capacity to the extraction of biomolecules. On the basis of the IL cations 1-ethyl-3-methylimidazolium and 1-butyl-3-methylimidazolium, the IL anion influence on ABS formation was assessed through their combination with chloride, bromide, acetate, hydrogensulfate, methanesulfonate, methylsulfate, ethylsulfate, trifluomethanesulfonate, trifluoroacetate, and dicyanamide. Ternary phase diagrams (and respective tic-lines) formed by these hydrophilic ILs, water, and the inorganic salt K(3)PO(4), were measured and are reported. The results indicate that the ability of an IL to induce ABS closely follows the decrease in the hydrogen bond accepting strength or the increase in the hydrogen bond acidity of the IL anion. In addition, the extraction capacity of the studied ABS was evaluated through their application to the extraction of an essential amino acid, L-tryptophan. It is shown that the partition coefficients obtained between the IL and the K(3)PO(4)-aqueous rich phases were substantially larger than those typically obtained with polymers-inorganic salts or polymers-polysaccharides aqueous systems.
publisher AMER CHEMICAL SOC
issn 1520-6106
year published 2009
volume 113
issue 27
beginning page 9304
ending page 9310
digital object identifier (doi) 10.1021/jp903286d
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000267651600034
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