On the Interactions between Amino Acids and Ionic Liquids in Aqueous Media
authors Tome, LIN; Dominguez-Perez, M; Claudio, AFM; Freire, MG; Marrucho, IM; Cabeza, O; Coutinho, JAP
nationality International
journal JOURNAL OF PHYSICAL CHEMISTRY B
keywords MUTUAL SOLUBILITIES; ENZYMATIC RESOLUTION; BIPHASIC SYSTEMS; 298.15 K; WATER; IMIDAZOLIUM; STABILITY; LIPASE; EXTRACTION; TOXICITY
abstract The understanding of the molecular-level interactions between biomolecules and ionic liquids (ILs) in aqueous C media is crucial for the optimization of a number of relevant biotechnological processes. In this work, the influence of a series of amino acids oil the liquid-liquid equilibria between 1-butyl-3-methylimidazolium tricyanomethane and water was studied to evaluate the preferential interactions between these three compounds. The solubility effects observed are dependent oil the polarity, size, and charge distribution of the amino acid side chains and are explained ill terms of a refined version of the model proposed earlier (Freire et al. J. Phys. Chem. B 2009, 113, 202; Tome et al. J. Phys. Chem. B 2009, 113, 2815) for ion specific effects oil aqueous solutions of imidazolium-based ILs. Although acting through different mechanisms, salting-in and salting-out phenomena possess a common basis which is the competition between water-amino acid side chain, IL-amino acid side chain, and water-IL interactions. The delicate balance between these interactions is dependent oil the relative affinities of the biomolecules to water molecules or to IL cation and anion and determines the trend and magnitude of the Solubility effect observed.
publisher AMER CHEMICAL SOC
issn 1520-6106
year published 2009
volume 113
issue 42
beginning page 13971
ending page 13979
digital object identifier (doi) 10.1021/jp906481m
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000270670800040

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