Selective recognition of tetrahedral dianions by a hexaaza cryptand receptor
authors Mateus, P; Delgado, R; Brandao, P; Carvalho, S; Felix, V
nationality International
journal ORGANIC & BIOMOLECULAR CHEMISTRY
keywords ANION COORDINATION CHEMISTRY; MOLECULAR-DYNAMICS; BINDING CONSTANTS; SPECIAL-ISSUE; FLUORIDE; MACROCYCLES; EQUILIBRIA; CYCLOPHANE; POLYAZA; WATER
abstract A hexaamine cage was synthesised in good yield by a [2+3] Schiff-base condensation followed by sodium borohydride reduction to be used as a receptor for the selective binding of anionic species. The protonation constants of the receptor, as well as its association constants with Cl(-), I(-), NO(3)(-), AcO(-), ClO(4)(-), H(2)PO(4)(-), SO(4)(2-), SeO(4)(2-) and S(2)O(3)(2-) were determined by potentiometry at 298.2 +/- 0.1 K in H(2)O-MeOH (50 : 50 v/v) and at ionic strength 0.10 +/- 0.01 mol dm(-3) in KTsO. These studies revealed a remarkable selectivity for dianionic tetrahedral anions by the protonated receptor, with association constants ranging 5.03-5.30 log units for the dianionic species and 1.49-2.97 log units for monoanionic ones. Single crystal X-ray determination of [(H(6)xyl)(SO(4))(H(2)O)(6)](SO(4))(2)center dot 9.5H(2)O showed that one sulfate anion is encapsulated into the receptor cage sited between the two 2,4,6-triethylbenzene caps establishing three N-H center dot center dot center dot O hydrogen bonds with two adjacent N-H binding sites and additional O-H center dot center dot center dot O hydrogen bonding interactions with six water of crystallization molecules. Four water molecules of the (SO(4))(H(2)O)(6) cluster interact with [H(6)xyl](6+) through N-H center dot center dot center dot O hydrogen bonds. Molecular dynamics simulations (MD) carried out with SO(4)(2-) and Cl-anions in H(2)O-MeOH (50 : 50 v/v) allowed the full understanding of anion molecular recognition, the selectivity of the protonated receptor for SO(4)(2-) and the role played by the methanol and water solvent molecules.
publisher ROYAL SOC CHEMISTRY
issn 1477-0520
year published 2009
volume 7
issue 22
beginning page 4661
ending page 4673
digital object identifier (doi) 10.1039/b912940e
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000271432300014
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journal analysis (jcr 2019):
journal impact factor 3.412
5 year journal impact factor 3.134
category normalized journal impact factor percentile 78.07
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