|
authors |
Daniel-da-Silva, AL; Fateixa, S; Guiomar, AJ; Costa, BFO; Silva, NJO; Trindade, T; Goodfellow, BJ; Gil, AM |
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nationality |
International |
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journal |
NANOTECHNOLOGY |
|
keywords |
DIFFERENTIAL SCANNING CALORIMETRY; IRON-OXIDE NANOPARTICLES; MINIEMULSION POLYMERIZATION; BIOMEDICAL APPLICATIONS; STARCH DERIVATIVES; DRUG-DELIVERY; PARTICLES; FUNCTIONALIZATION; CARBOXYMETHYLATION; MICROGELS |
|
abstract |
Magnetic hydrogel kappa-carrageenan nanospheres were successfully prepared via water-in-oil (w/o) microemulsions combined with thermally induced gelation of the polysaccharide. The size of the nanospheres (an average diameter (empty set) of about 50 and 75 nm) was modulated by varying the concentration of surfactant. The nanospheres contained superparamagnetic magnetite nanoparticles (empty set 8 nm), previously prepared by co-precipitation within the biopolymer. Carboxyl groups, at a concentration of about 4 mmol g(-1), were successfully grafted at the surface of these magnetic nanospheres via carboxymethylation of the kappa-carrageenan. The carboxylated nanospheres were shown to be thermo-sensitive in the 37-45 degrees C temperature range, indicating their potential as thermally controlled delivery systems for drugs and/or magnetic particles at physiological temperatures. Finally, preliminary results have been obtained for IgG antibody conjugation of the carboxylated nanospheres and the potential of these systems for bio-applications is discussed. |
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publisher |
IOP PUBLISHING LTD |
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issn |
0957-4484 |
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year published |
2009 |
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volume |
20 |
|
issue |
35 |
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digital object identifier (doi) |
10.1088/0957-4484/20/35/355602 |
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web of science category |
Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied |
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subject category |
Science & Technology - Other Topics; Materials Science; Physics |
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unique article identifier |
WOS:000268911500014
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