NMR metabonomics for mammalian cell metabolism studies
authors Duarte, IF; Lamego, I; Rocha, C; Gil, AM
nationality International
journal BIOANALYSIS
keywords MAGNETIC-RESONANCE-SPECTROSCOPY; CHOLINE PHOSPHOLIPID-METABOLISM; IN-VITRO H-1-NMR; HIGH-RESOLUTION; INDUCED APOPTOSIS; MOBILE LIPIDS; CANCER-CELLS; PHARMACODYNAMIC MARKERS; GLUCOSE-METABOLISM; CARCINOMA-CELLS
abstract The detailed knowledge of mammalian cell metabolism and its adjustments to different cell properties and perturbations, such as disease and drug exposure, is of enormous value in the deeper understanding of pathological processes and drug mechanisms, as well as in the development of new and improved methods for diagnosis, follow-up of disease progression and treatment response. This review covers recent developments in the use of NMR-based metabonomics to characterize cellular metabolomes and interpret them in terms of metabolic changes taking place in a wide range of situations. The analytical methodology available is briefly presented and the applications developed so far are reviewed. These include differences in cell properties (e.g., drug resistance, cell cycle stage, specific growth conditions and genetic characteristics) and changes induced in response to different perturbations (e.g., disease, drug exposure and irradiation).
publisher FUTURE SCI LTD
issn 1757-6180
year published 2009
volume 1
issue 9
beginning page 1597
ending page 1614
digital object identifier (doi) 10.4155/BIO.09.151
web of science category Biochemical Research Methods; Chemistry, Analytical
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000281410000015
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  impact metrics
journal analysis (jcr 2017):
journal impact factor 2.478
5 year journal impact factor 2.451
category normalized journal impact factor percentile 59.322
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