Biocellulose Membranes as Supports for Dermal Release of Lidocaine
authors Trovatti, E; Silva, NHCS; Duarte, IF; Rosado, CF; Almeida, IF; Costa, P; Freire, CSR; Silvestre, AJD; Neto, CP
nationality International
journal BIOMACROMOLECULES
keywords MOLECULARLY IMPRINTED POLYMER; CONTROLLED DRUG-DELIVERY; BACTERIAL CELLULOSE; TRANSDERMAL DELIVERY; RACEMIC PROPRANOLOL; MICROBIAL CELLULOSE; COMPOSITE MEMBRANE; BIOMATERIALS; ABSORPTION; SYSTEM
abstract Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.
publisher AMER CHEMICAL SOC
issn 1525-7797
year published 2011
volume 12
issue 11
beginning page 4162
ending page 4168
digital object identifier (doi) 10.1021/bm201303r
web of science category Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science
subject category Biochemistry & Molecular Biology; Chemistry; Polymer Science
unique article identifier WOS:000296830600039
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journal analysis (jcr 2019):
journal impact factor 6.092
5 year journal impact factor 5.775
category normalized journal impact factor percentile 92.195
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