4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
authors Loughzail, M; Fernandes, JA; Baouid, A; Essaber, M; Cavaleiro, JAS; Paz, FAA
nationality International
journal ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
keywords BENZODIAZEPINE RECEPTORS; TRIMESIC ACID; 1,5-BENZODIAZEPINES; MONOHYDRATE; DERIVATIVES
abstract 4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the presence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C18H14N2O. In the molecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)degrees]. In the crystal, the molecules are linked by C-H center dot center dot center dot O and C-H center dot center dot center dot N interactions.
publisher WILEY-BLACKWELL
issn 1600-5368
year published 2011
volume 67
beginning page O2075
ending page U879
digital object identifier (doi) 10.1107/S1600536811027371
web of science category Crystallography
subject category Crystallography
unique article identifier WOS:000294615300073
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