Impact of magnetic nanofillers in the swelling and release properties of kappa-carrageenan hydrogel nanocomposites
authors Daniel-da-Silva, AL; Moreira, J; Neto, R; Estrada, AC; Gil, AM; Trindade, T
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Carrageenan; Hydrogels; Nanocomposites; Swelling; Drug release; Magnetite
keywords DRUG-RELEASE; CHITOSAN-ALGINATE; SIGMOIDAL RELEASE; DELIVERY-SYSTEMS; MATRIX TABLETS; NANOPARTICLES; BEHAVIOR; GELS; FORMULATIONS; PH
abstract Natural polysaccharides such as kappa-carrageenan are an important class of biomaterials for drug delivery. The incorporation of magnetic nanoparticles in polysaccharide hydrogels is currently being explored as a strategy to confer to the hydrogels novel functionalities valuable for specific bio-applications. Within this context, kappa-carrageenan magnetic hydrogel nanocomposites have been prepared and the effect of magnetic (Fe(3)O(4)) nanofillers in the swelling of the hydrogels and in the release kinetics and mechanism of a model drug (methylene blue) has been investigated. In vitro release studies demonstrated the applicability of the composites in sustained drug release. The mechanism controlling the release seems to be determined by the strength of the gel network and the extent of gel swelling, both being affected by the incorporation of nanofillers. Furthermore, it was demonstrated that the release rate and profile could be tailored using variable Fe(3)O(4) nanoparticles load. Thus, this seems to be a promising strategy for the development of drug delivery systems with tailored released behavior. (C) 2011 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0144-8617
year published 2012
volume 87
issue 1
beginning page 328
ending page 335
digital object identifier (doi) 10.1016/j.carbpol.2011.07.051
web of science category Chemistry, Applied; Chemistry, Organic; Polymer Science
subject category Chemistry; Polymer Science
unique article identifier WOS:000297389000043
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 5.158
5 year journal impact factor 5.326
category normalized journal impact factor percentile 93.599
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg