Zeolite Structures Loading with an Anticancer Compound As Drug Delivery Systems

authors	Amorim, R; Vilaca, N; Martinho, O; Reis, RM; Sardo, M; Rocha, J; Fonseca, AM; Baltazar, F; Neves, IC
nationality	International
journal	JOURNAL OF PHYSICAL CHEMISTRY C
keywords	SULFONAMIDE ANTIBIOTICS; SYNTHETIC ZEOLITES; HUMAN-MELANOMA; HOST-GUEST; Y ZEOLITE; IN-VITRO; CANCER; NANOPARTICLES; RELEASE; CELLS
abstract	Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of alpha-cyano-4-hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, H-1 NMR, C-13 and Al-27 solid-state MAS NMR, and UV-vis), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell death.
publisher	AMER CHEMICAL SOC
issn	1932-7447
year published	2012
volume	116
issue	48
beginning page	25642
ending page	25650
digital object identifier (doi)	10.1021/jp3093868
web of science category	Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category	Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier	WOS:000311921900060