Tunable transmembrane chloride transport by bis-indolylureas
authors Haynes, CJE; Moore, SJ; Hiscock, JR; Marques, I; Costa, PJ; Felix, V; Gale, PA
nationality International
journal CHEMICAL SCIENCE
keywords AMBER FORCE-FIELD; ORGANIC-SOLVENTS; ANION RECEPTORS; LIPID-BILAYERS; PHOSPHOLIPID-BILAYERS; BINDING-PROPERTIES; CYSTIC-FIBROSIS; GELATORS; CHANNEL; PRODIGIOSINS
abstract A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayers.
publisher ROYAL SOC CHEMISTRY
issn 2041-6520
year published 2012
volume 3
issue 5
beginning page 1436
ending page 1444
digital object identifier (doi) 10.1039/c2sc20041d
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000302319000009
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journal analysis (jcr 2017):
journal impact factor 9.063
5 year journal impact factor 8.757
category normalized journal impact factor percentile 89.766
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