Partition Coefficients of Alkaloids in Biphasic Ionic-Liquid-Aqueous Systems and their Dependence on the Hofmeister Series
authors Freire, MG; Teles, ARR; Lopes, JNC; Rebelo, LPN; Marrucho, IM; Coutinho, JAP
nationality International
journal SEPARATION SCIENCE AND TECHNOLOGY
author keywords alkaloid; caffeine; Hofmeister series; ionic liquid; nicotine; partition coefficient
keywords CAPILLARY GAS-CHROMATOGRAPHY; MUTUAL SOLUBILITIES; PHARMACEUTICAL FORMULATIONS; LACTIC-ACID; EXTRACTION; WATER; NICOTINE; CAFFEINE; QUANTIFICATION; PRECIPITATION
abstract The aim of this work is to test the potential of hydrophobic phosphonium-based ionic liquids for the extraction of caffeine and nicotine from aqueous phases through the determination of the alkaloids' partition coefficients. It was found that the caffeine partitioning for the ionic-liquid-rich phase increases with the ionic liquid hydrogen-bonding accepting capability (or water content), while for nicotine a nearly opposite behavior was observed. In addition, both the influence of the ionic concentration of the aqueous solution (ranging from 0.0 mol . kg(-1) to 3.0 mol . kg(-1)), and the salt nature (with K- and Na-based salts), in the partitioning of caffeine for the ionic-liquid-rich phase were investigated. The influence of the inorganic salt nature in the alkaloid partitioning for the ionic-liquid-rich phase closely follows the Hofmeister series.
publisher TAYLOR & FRANCIS INC
issn 0149-6395
year published 2012
volume 47
issue 2
beginning page 284
ending page 291
digital object identifier (doi) 10.1080/01496395.2011.620585
web of science category Chemistry, Multidisciplinary; Engineering, Chemical
subject category Chemistry; Engineering
unique article identifier WOS:000302412700013

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