Can Biofluids Metabolic Profiling Help to Improve Healthcare during Pregnancy?
authors Graca, G; Diaz, SO; Pinto, J; Barros, AS; Duarte, IF; Goodfellow, BJ; Galhano, E; Pita, C; Almeida, MD; Carreira, IM; Gil, AM
nationality International
journal SPECTROSCOPY-AN INTERNATIONAL JOURNAL
author keywords Prenatal health; pregnancy; diagnosis; diabetes; preterm; trisomy; amniotic fluid; urine blood; metabolomics; metabonomics; NMR; multivariate analysis
keywords NUCLEAR-MAGNETIC-RESONANCE; TRIMESTER AMNIOTIC-FLUID; PRENATAL DISORDERS; NMR-SPECTROSCOPY; MATERNAL URINE; BIOMARKERS; 2ND; METABONOMICS; PREECLAMPSIA; PLASMA
abstract This paper describes a metabonomics study of 2nd trimester biofluids (amniotic fluid, maternal urine, and blood plasma), in an attempt to correlate biofluid metabolic changes with suspected/diagnosed fetal malformations (FM) and chromosomal disorders as well as with later occurring gestational diabetes mellitus (GDM), preterm delivery (PTD), and premature rupture of membranes (PROM). The global biochemical picture given by the threesome of biofluids should enable the definition of potential disease signatures and unveil potential metabolite markers for clinical use in predictive prenatal diagnostics. Results show that relatively strong metabolic disturbances accompany FM, reflected in all three biofluids and thus suggesting the involvement of both fetal and maternal metabolisms. Regarding GDM, amniotic fluid and maternal urine seem potential good media to detect early metabolic changes, and PTD subjects show small metabolite changes in the same biofluids, undergoing work being focused on plasma composition. Chromosomal disorders show an interestingly marked effect on maternal urine, whereas no statistically relevant early changes have been observed for PROM subjects. Interestingly, in the case of FM and chromosomal disorders, maternal biofluids show some sensitivity to disorder type, for example, for central nervous system malformations and trisomy 21, respectively. These results show the usefulness of biofluid metabonomics to probe overall metabolic disturbances in relation to prenatal disorders.
publisher HINDAWI PUBLISHING CORPORATION
issn 0712-4813
year published 2012
volume 27
issue 5-6
beginning page 515
ending page 523
digital object identifier (doi) 10.1155/2012/128367
web of science category Biochemical Research Methods; Spectroscopy
subject category Biochemistry & Molecular Biology; Spectroscopy
unique article identifier WOS:000306505500031

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