Synthesis, characterization, and liposome partition of a novel tetracycline derivative using the ionic liquids framework
authors Alves, F; Oliveira, FS; Schroder, B; Matos, C; Marrucho, IM
nationality International
journal JOURNAL OF PHARMACEUTICAL SCIENCES
author keywords Tetracycline; Docusate; Ionic Liquids; Synthesis; Drug-like properties; Solubility; Partition Coefficient; Liposomes; UV-VIS spectroscopy
keywords ACTIVE PHARMACEUTICAL INGREDIENTS; HYDROCHLORIDE FORMS; COEFFICIENTS; ANTIBIOTICS; SOLUBILITY; CIPROFLOXACIN; SOLVENTS; SALTS; WATER
abstract Recently, efforts have been put on the development of new drug formulations using ionic liquid framework. In this work, two different species of abroad-spectrum polyketide antibiotic, tetracycline, are studied in terms of some important properties for antibiotics such as solubility in water and hydrophilichydrophobic balance. Tetracycline was used as cation, whereas docusate, a biocompatible anion, which enables the tailoring of the hydrophilicity of salts, was chosen as the anion. The developed innovative ion pair, tetracycline docusate, was characterized in terms of its thermal stability, water solubility, octanolwater, and liposomewater partition coefficients, using UVvis spectrophotometry because of the absorbance of tetracycline around 270nm. Egg yolk phosphatidylcholine liposomes were used as cell membrane models, and the interactions of both tetracycline hydrochloride and tetracycline docusate with the liposomes were quantified by determination of the partition coefficient using derivative spectrophotometry. A theoretical model based on simple partition drugs between two different media was used to determine the partition coefficient in liposomes. (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:15041512, 2013
publisher WILEY-BLACKWELL
issn 0022-3549
year published 2013
volume 102
issue 5
beginning page 1504
ending page 1512
digital object identifier (doi) 10.1002/jps.23487
web of science category Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy; Chemistry
unique article identifier WOS:000317620200012
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journal analysis (jcr 2017):
journal impact factor 3.075
5 year journal impact factor 2.950
category normalized journal impact factor percentile 63.252
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