Novel route for rapid sol-gel synthesis of hydroxyapatite, avoiding ageing and using fast drying with a 50-fold to 200-fold reduction in process time
authors Ben-Arfa, BAE; Salvado, IMM; Ferreira, JMF; Pullar, RC
nationality International
journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords Hydroxyapatite; beta-TCP; Nanoparticles; Nano-synthesis; Biocompatibility; Sol-gel
keywords MECHANOCHEMICAL SYNTHESIS; PRECIPITATION PROCESS; CHEMICAL-SYNTHESIS; POWDERS; PHOSPHATE
abstract We have developed an innovative, rapid sol-gel method of producing hydroxyapatite nanopowders that avoids the conventional lengthy ageing and drying processes (over a week), being 200 times quicker in comparison to conventional aqueous sol-gel preparation, and 50 times quicker than ethanol based sol-gel synthesis. Two different sets of experimental conditions, in terms of pH value (5.5 and 7.5), synthesis temperature (45 and 90 degrees C), drying temperature (60 and 80 degrees C) and calcination temperature (400 and 700 degrees C) were explored. The products were characterised by X-ray diffraction (XRD) Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and specific surface area (SSA) measurements. Pure hydroxyapatite (Ca-10(PO4)(6)(OH)(2), HAp) was obtained for the powders synthesised at pH 7.5 and calcined at 400 degrees C, while biphasic mixtures of HAp/beta-tricalcium phosphate ((beta-Ca-3(PO4)(2), TCP) were produced at pH 5.5 and (pH 7.5 at elevated temperature). The novel rapid drying was up to 200 times faster than conventional drying, only needing 1 h with no prior ageing step, and favoured the formation of smaller/finer nanopowders, while producing pure HAp or phase mixtures virtually identical to those obtained from the slow conventional drying method, despite the absence of a slow ageing process. The products of this novel rapid process were actually shown to have smaller crystallite sizes and larger SSA, which should result in increased bioactivity. (C) 2016 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0928-4931
year published 2017
volume 70
beginning page 796
ending page 804
digital object identifier (doi) 10.1016/j.msec.2016.09.054
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000388046900093
  ciceco authors
  impact metrics
times cited (wos core): 3
journal impact factor (jcr 2016): 4.164
5 year journal impact factor (jcr 2016): 3.926
category normalized journal impact factor percentile (jcr 2016): 74.242
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