Multilayered materials based on biopolymers as drug delivery systems
authors Vilela, C; Figueiredo, ARP; Silvestre, AJD; Freire, CSR
nationality International
source EXPERT OPINION ON DRUG DELIVERY
author keywords Biopolymers; capsules; controlled drug delivery; films; layer-by-layer assembly; multilayered materials
keywords plus LAYER-BY-LAYER; SELF-ASSEMBLY PROCESS; TEMPLATED POLYELECTROLYTE NANOCAPSULES; MESOPOROUS SILICA NANOPARTICLES; CATIONIC BIPOLAR AMPHIPHILES; CONTROLLED-RELEASE; INTRACELLULAR DELIVERY; CHARGED SURFACES; CELLULAR UPTAKE; BIOMEDICAL APPLICATIONS
abstract Introduction: The design of efficient therapeutic delivery devices has become a tremendously active area of research with a strong contribution from the layer-by-layer (LbL) technology. The application of this simple yet firmly established technique for the design of drug reservoirs originates a multitude of multilayered systems of tailored architecture and with a high level of control of drug administration. Areas covered: This review will focus on the most recent and original research on LbL assemblies based on biopolymers including polysaccharides, polypeptides and proteins, with potential use in drug delivery. Herein, drug reservoirs consisting of multilayered planar films and capsules will be examined with emphasis on the ones benefiting from the non-cytotoxic and biocompatible nature of biopolymers, which are suitable to load, protect and release a high payload of toxic and fragile drugs. Expert opinion: The combination of biopolymers with LbL technology has undergone extensive research, still, there is a multitude of R&D opportunities for the design of smart drug delivery systems with distinct multilayered morphologies, low immunological response, non-invasive drug release devices, as well as the design of theranostic systems combining diagnostics and therapeutic features. Further developments in terms of scaling towards mass production in the pharmaceutical industry are expected in the long-term.
publisher TAYLOR & FRANCIS LTD
issn 1742-5247
year published 2017
digital object identifier (doi) 10.1080/17425247.2016.1214568
web of science category Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy
unique article identifier WOS:000393792400006
  ciceco authors
  impact metrics
times cited (wos core): 0
journal impact factor (jcr 2015): 4.840
5 year journal impact factor (jcr 2015): 5.021
category normalized journal impact factor percentile (jcr 2015): 90.392
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