Poly(N-methacryloyl glycine)/nanocellulose composites as pH-sensitive systems for controlled release of diclofenac
authors Saidi, L; Vilela, C; Oliveira, H; Silvestre, AJD; Freire, CSR
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Bacterial nanocellulose; Controlled release; Diclofenac sodium salt; Drug delivery; pH-responsiveness; Poly(N-methacryloyl glycine)
keywords BACTERIAL CELLULOSE MEMBRANES; DRUG-DELIVERY SYSTEMS; AMINO-ACID MOIETIES; BIOCELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; POLYMERIZATION; DISSOLUTION; NANOCOMPOSITES; METHACRYLATE; LIDOCAINE
abstract The present study reports the development of non-cytotoxic and pH-sensitive nanostructured membranes consisting of a polymer with amino acid pending moieties and bacterial nanocellulose (BC). The nanocomposites were prepared through a simple methodology under green reaction conditions. The obtained materials display good thermal stability (up to 200 degrees C), viscoelastic (storage modulus > 700 MPa) and mechanical (Young's modulus =3.5-4.9 GPa) properties, together with high water uptake capacity. The results of the in vitro MTT assay showed that the nanocomposites are non-cytotoxic to HaCaT cells for 72 h. The in vitro release profile of diclofenac sodium salt (DCF) from the nanocomposites into simulated body fluids at different pH values demonstrates the pH-responsive behaviour of these materials. Besides, DCF is mainly retained in the nanocomposites at pH 2.1 and released at pH 7.4, revealing their potential for the controlled release of DCF in dermal as well as in oral drug delivery applications. (C) 2017 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0144-8617
year published 2017
volume 169
beginning page 357
ending page 365
digital object identifier (doi) 10.1016/j.carbpol.2017.04.030
web of science category Chemistry, Applied; Chemistry, Organic; Polymer Science
subject category Chemistry; Polymer Science
unique article identifier WOS:000402343000041
  ciceco authors
  impact metrics
times cited (wos core): 0
journal impact factor (jcr 2016): 4.811
5 year journal impact factor (jcr 2016): 5.130
category normalized journal impact factor percentile (jcr 2016): 90.105
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