Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet
authors Salvador, AC; Krol, E; Lemos, VC; Santos, SAO; Bento, FPMS; Costa, CP; Almeida, A; Szczepankiewicz, D; Kulczynski, B; Krejpcio, Z; Silvestre, AJD; Rocha, SM
nationality International
journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
author keywords diabetic rats; elderberry extracts supplementation; high-fat diet; lipophilic extract; polar extract; Sambucus nigra L.
keywords ANTIOXIDANT PROPERTIES; MELLITUS; ANTHOCYANINS; POLYPHENOLS; RESISTANCE; MANAGEMENT; DISORDERS; DIAGNOSIS; CULTIVARS; INDEXES
abstract Elderberry (Sambucus nigra L.) lipophilic and polar extract dietary supplementation effects were evaluated according to diabetes management indices, using an in vivo model. A research pipeline was constructed, that ranged from extract preparation, partial chemical characterization and toxicity evaluation, to examining the elderberry extract dietary supplementation effects on biofluid and tissues. Extracts toxicity was screened using an Aliivibrio fischeri bioluminescence model. A concentration of up to 60 mg/L was selected, and rat doses for oral supplementation were computed applying the interspecies correlation between A. fischeri and rats. Wistar type 2 diabetic rats, induced by streptozotocin (STZ), were fed a high-fat diet and supplemented for 4 weeks at doses of 190 and 350 mg/kg body weight/day of lipophilic and polar extract, respectively. As far as we know, lipophilic elderberry extract supplementation was assessed for the first time, while polar extract was administrated at higher doses and for a shorter period compared to previous studies, aiming to evaluate subacute supplementation effects. The polar extract modulated glucose metabolism by correcting hyperglycemia, while the lipophilic extract lowered insulin secretion. Both extracts lowered insulin resistance, without remarkable alterations to hematological indices, sera lipids and sera and tissular trace element homeostasis. In conclusion, elderberries are a potential source of bioactive compounds for formulations to be used as co-adjuvants in diabetes management.
publisher MDPI AG
issn 1422-0067
year published 2017
volume 18
issue 1
digital object identifier (doi) 10.3390/ijms18010013
web of science category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000393030600013
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journal analysis (jcr 2017):
journal impact factor 3.687
5 year journal impact factor 3.878
category normalized journal impact factor percentile 69.668
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