IRMOF-3 Biological Activity Enhancement by Post-Synthetic Modification
authors Abdelhameed, RM; Darwesh, OM; Rocha, J; Silva, AMS
nationality International
journal EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
author keywords Metal-organic frameworks; Post-synthetic modification; Antifungal; Antibacterial; Structural characterization
keywords METAL-ORGANIC FRAMEWORKS; ANTIMICROBIAL ACTIVITY; DERIVATIVES; CHITOSAN; MOFS
abstract The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions. In this context, metal-organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal- and metal oxide-nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF-3 was modified with 2,5-dimethoxytetrahydrofuran, N,N '-disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, respectively, IRMOF-3-FU, IRMOF-3-SU, IRMOF-3-AC, IRMOF-3-DL in 38 to 90 % yields. Remarkably, the biological activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of commercial antibiotics.
publisher WILEY-V C H VERLAG GMBH
issn 1434-1948
isbn 1099-0682
year published 2019
issue 9
beginning page 1243
ending page 1249
digital object identifier (doi) 10.1002/ejic.201801442
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000460581100008
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journal analysis (jcr 2019):
journal impact factor 2.529
5 year journal impact factor 2.284
category normalized journal impact factor percentile 65.556
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