Optical sensors for detection of nano-molar Zn2+ in aqueous medium: Direct evidence of probe- Zn2+ binding by single crystal X-ray structures
authors Mahiuddin, M; Banerjee, M; Shaikh, A; Shyam, T; Taniya, S; Ghosh, A; Adhikary, A; Brandao, P; Felix, V; Das, D
nationality International
journal JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
author keywords Zn2+; Fluorescence; Bare eye; Nano-molar; Sensors; Crystal structure; Cell imaging
keywords PHOTOINDUCED ELECTRON-TRANSFER; TURN-ON; FLUORESCENT SENSOR; SCHIFF-BASE; SELECTIVE DETECTION; ZINC SENSOR; IONS; CHEMOSENSOR; PET; RELEASE
abstract Two simple probes, derived by condensation of ethylenediamine with 3-ethoxysalicylaldehyde (L) and salicylaldehyde (L1) have been exploited for selective recognition of Zn2+. The interaction between probes and Zn2+ has been established by spectroscopic techniques and confirmed by single crystal X-ray structures of the resulting Zn2+ complexes. It is proposed that Zn2+ inhibits the PET process, originally responsible for non-emissive nature of free ligand and turns the fluorescence ON through CHEF process. The L and L1 probes respectively detect as low as 1.8 nM and 1.16 nM Zn2+, while corresponding binding constants are 2.9 x 10(6) M-1 and 4.57 x 10(5) M-1. L1 is very effective for intra-celullar imaging of Zn2+ in HeLa and MDA-MB-468 cells. The density functional theoretical studies unveil the energy parameters involved in the probe-Zn2+ interaction process.
publisher ELSEVIER SCIENCE SA
issn 1010-6030
year published 2019
volume 368
beginning page 52
ending page 61
digital object identifier (doi) 10.1016/j.jphotochem.2018.09.009
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000452575600007
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