Recent trends on the development of systems for cancer diagnosis and treatment by microfluidic technology
authors Silva, ACQ; Vilela, C; Santos, HA; Silvestre, AJD; Freire, CSR
nationality International
journal APPLIED MATERIALS TODAY
author keywords Microfluidic technology; Lab-on-a-chip; Cancer diagnosis; Drug delivery systems; Cancer therapy
keywords CIRCULATING TUMOR-CELLS; DRUG-DELIVERY SYSTEMS; ONE-STEP FABRICATION; LABEL-FREE ISOLATION; POLYMERIC NANOPARTICLES; RECENT PROGRESS; GENEXOL-PM; PHASE-I; CHIP; PLATFORM
abstract Cancer is the second leading cause of non-accidental death in the world, accounting for roughly 9.6 million deaths in 2018. In the latter years, research in this domain has grown exponentially, as a way to provide deep insights into this malignancy, but also new tools for early diagnosis and efficient personalized treatment options. Microfluidic lab-on-a-chip technology has demonstrated a high potential on the design of new methodologies for cancer diagnosis, treatment and disease follow-up. Here, we present a detailed review on the application of the microfluidic platforms for the detection and separation of tumour cells from blood (liquid biopsy) and the development of new drug delivery systems for cancer conquering. (C) 2019 Elsevier Ltd. All rights reserved.
publisher ELSEVIER
issn 2352-9407
year published 2020
volume 18
digital object identifier (doi) 10.1016/j.apmt.2019.100450
web of science category Materials Science, Multidisciplinary
subject category Materials Science
unique article identifier WOS:000530651300007
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 8.352
5 year journal impact factor 8.383
category normalized journal impact factor percentile 89.331
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