Novel Biodegradable Laminarin Microparticles for Biomedical Applications
authors Castanheira, EJ; Correia, TR; Rodrigues, JMM; Mano, JE
nationality International
journal BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
author keywords Marine polysaccharides; Laminarin; Microparticles
keywords CELL-ADHESION; CANCER; HYDROGEL; MICROSPHERES; FABRICATION; PARTICLES; INDUCTION; APOPTOSIS; ACID
abstract Fabrication of biocompatible polymeric carriers for sustained/controlled drug-delivery have been extensively explored over the years. Furthermore, systems based on polymers from natural origins exceed conventional polymers in biocompatibility, biodegradability and cost efficiency. Polysaccharides are one of the most common biopolymers found in nature and they can achieve a high degree of complexity and fine biological properties. Herein, is proposed a biodegradable and biocompatible microcarrier synthesized from laminarin, a low Mw marine polysaccharide based on glucose units with great biological activity, such as immune modulation and antimicrobial properties. Within this work, controlled size microparticles were obtained from novel modifications of laminarin. Microparticles showed 40% release of fluorescein isothiocyanatedextran (70 kDa) after 24 h and full degradability after 11 days, when in physiological conditions. When incubated with human adipose stem and L929 cell lines (up to a microparticle concentration of 100 mu g/mL) no cytotoxicity was perceived, and neither membrane or nucleus disturbance. Thus, microparticles synthesized from laminarin, proved to be a cost efficient, biocompatible and biodegradable system.
publisher CHEMICAL SOC JAPAN
issn 0009-2673
isbn 1348-0634
year published 2020
volume 93
issue 6
beginning page 713
ending page 719
digital object identifier (doi) 10.1246/bcsj.20200034
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000540717800001
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journal impact factor 4.488
5 year journal impact factor 2.697
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