|
authors |
Rocha, DHA; Batista, VF; Balsa, EJF; Pinto, DCGA; Silva, AMS |
|
nationality |
International |
|
journal |
MOLECULES |
|
author keywords |
chromene-3-carbaldehydes; 3-styryl-2H-chromenes; quinoline-3-carbaldehydes; 3H-chromeno[3; 4-c]quinolines; 3-styrylquinoline-1(2H)-carbaldehydes; Wittig reaction |
|
keywords |
BIOLOGICAL EVALUATION; AGENTS; CHROMONE-3-CARBOXALDEHYDES; CYTOTOXICITY; INHIBITORS; QUINOLINE; DESIGN |
|
abstract |
Chromenes and quinolines are recognized as important scaffolds in medicinal chemistry. Herein, the efficient use of chromene- and quinoline-3-carbaldehydes to synthesize other valuable heterocycles is described. These carbaldehydes are obtained in excellent yields through the Vilsmeyer-Haack reaction of flavanones and azaflavanones. Protocols towards the synthesis of new heterocycles, such as 3H-chromeno[3-c]quinolines, (Z/E)-2-aryl-4-chloro-3-styryl-2H-chromenes, and (E)-2-aryl-4-chloro-3-styrylquinoline-1(2H)-carbaldehydes were established. Altogether, we demonstrate the value of chromene- and quinoline-3-carbaldehydes as building blocks. |
|
publisher |
MDPI |
|
isbn |
1420-3049 |
|
year published |
2020 |
|
volume |
25 |
|
issue |
17 |
|
digital object identifier (doi) |
10.3390/molecules25173791 |
|
web of science category |
Biochemistry & Molecular Biology; Chemistry, Multidisciplinary |
|
subject category |
Biochemistry & Molecular Biology; Chemistry |
|
unique article identifier |
WOS:000569658600001
|
