authors |
Pinho, SLC; Faneca, H; Geraldes, CFGC; Rocha, J; Carlos, LD; Delville, MH |
nationality |
International |
journal |
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY |
author keywords |
Nanoparticles; Imaging agents; Luminescence; Bimodal imaging; MRI contrast agents |
keywords |
CONTRAST AGENTS; QUANTUM DOTS; GAMMA-AMINOPROPYLTRIETHOXYSILANE; INORGANIC NANOPARTICLES; LANTHANIDE COMPLEXES; LUMINESCENT PROBES; RADIO-OPAQUE; FLUORESCENT; SURFACE; EUROPIUM(III) |
abstract |
Bimodal magnetic resonance imaging (MRI)/optical probes for bioimaging were obtained by grafting two types of lanthanide metal ions, Gd3+ and Eu3+/Tb3+, on the surface of SiO2 nanoparticles. The resulting systems were endowed with relaxometry and photoluminescent properties, respectively. Grafting a pyridine-based aromatic backbone on to the silica surface enhances the emission quantum yield of the Eu3+-containing nanoparticles fivefold compared to similar systems that bear no aromatic antennae. The emission properties of the mixed Ln3+/Gd3+-based nanoparticles are not influenced by the presence of Gd3+. The relaxometric properties of these samples are slightly better than the properties of commercial [Gd(DTPA)]2 (DTPA = diethylenetriaminepentaacetate). When taken up by RAW 264.7 cells (mouse macrophage cell line), such bimodal probes exhibit both T1-weighted MRI increased contrast and fluorescence tracking. |
publisher |
WILEY-V C H VERLAG GMBH |
issn |
1434-1948 |
year published |
2012 |
issue |
16 |
beginning page |
2828 |
ending page |
2837 |
digital object identifier (doi) |
10.1002/ejic.201101110 |
web of science category |
Chemistry, Inorganic & Nuclear |
subject category |
Chemistry |
unique article identifier |
WOS:000304089700031
|