Recent Advances in Analytical Techniques Volume: 4
authors Ana P. M. Tavares, Márcia C. Neves, Tito Trindade and Mara G. Freire
editors Bentham Science
chapter title Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials
edition 1st
nationality International
author keywords (Bio)pharmaceuticals, Purification Techniques, Downstream Processing, Nanotechnology, Silica (Nano)particles, Carbon-based (Nano)particles, Magnetic (Nano)particles, Pharmaceuticals Manufacturing, Solid-phase Extraction, Solid-liquid Extraction.
abstract Biopharmaceuticals main classes comprise recombinant proteins, antibodies, and nucleic-acid-derived products, while synthetic pharmaceuticals include a wide variety of organic compounds. The purification of (bio)pharmaceuticals, as part of downstream processing, is mainly carried out by chromatographic processes, which are responsible for the therapeutics high cost. Therefore, there is a crucial need on the development of novel and more efficient separation/purification processes or on the improvement of the current chromatographic-based ones, aiming at producing pharmaceuticals of high quality and at a lower cost. Amongst alternative techniques, it has been demonstrated that inorganic or organic (nano)particles, used in solid-phase extraction approaches, may be promising for the purification of (bio)pharmaceuticals. This chapter provides an overview on solid-liquid separation/purification processes used to obtain high purity and high quality pharmaceuticals. The main purification processes are described and summarized. The areas where there has been a sustainable progress, combined with improved therapeutic characteristics, are highlighted. Materials based on silica (nano)particles, carbon-based (nano)particles (carbon nanotubes, graphene and activated carbon) and magnetic (nano)particles are overviewed. Based on the reported results, nanotechnology may play a key role in future pharmaceutical developments and manufacturing, where the design of suitable functionalized (nano)particles is a crucial factor to enhance the selectivity and to obtain high purification and recovery yields of (bio)pharmaceuticals.
isbn 978-981-14-0510-5
year published 2020
beginning page 58
ending page 93
book digital object identifier (doi) 10.2174/9789811405112119040001
link http://www.eurekaselect.com/177741/chapter/recovery-and-purification-of-%28bio%29pharmaceuticals-using-%28nano%29material

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